2023

54. Monaghan MG, Borah R, Thomsen C, Browne S. Thou shall not heal: Overcoming the non-healing behavior of diabetic foot ulcers by engineering the inflammatory microenvironment. Advanced Drug Delivery Reviews (2023). 115120

53. Margarida Barroso, Michael G. Monaghan, Raluca Niesner, Ruslan I. Dmitriev. Probing organoid metabolism using Fluorescence Lifetime Imaging Microscopy (FLIM): the next frontier of drug discovery and disease understanding. Advanced Drug Delivery Reviews. In Press August 2023, https://doi.org/10.1016/j.addr.2023.1150

52. M Solazzo, MG Monaghan. A workflow to produce a low-cost in vitro platform for the electric-field pacing of cellularised 3D porous scaffolds. ACS Biomaterials Science and Engineering. 2023, 9, 8, 4573–4582

51. Farhad Chariyev-Prinz, Nuno Neto, Michael G. Monaghan, Daniel J. Kelly.Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure, Journal of Tissue Engineering and Regenerative Medicine, In Press 2023. https://doi.org/10.1155/2023/99761

50. Giuseppe A. Asaro, Matteo Solazzo, Meenakshi Suku, Dahnan Spurling, Katelyn Genoud, Javier Gutierrez Gonzalez, Fergal J. O’ Brien, Valeria Nicolosi & Michael G. Monaghan. MXene functionalized collagen biomaterials for cardiac tissue engineering driving iPSC-derived cardiomyocyte maturation. npj 2D Mater Appl 7, 44 (2023). https://doi.org/10.1038/s41699-023-00409-w

49. F. Chariyev-Prinz, A. Szojka, N. Neto, R. Burdis, M. G. Monaghan and D. J. Kelly. An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis. Journal of Biomechanics. 2023 Vol. 154 Pages 111590.

48. Conor Darroch, Giuseppe A. Asaro, Coralie Gréant, Meenakshi Suku, Nele Pien, Sandra van Vlierberghe, Michael G. Monaghan. Melt Electrowriting of a Biocompatible Photo‐Crosslinkable Poly(D,L-lactic acid)/Poly(ε‐Caprolactone)‐Based Material with Tunable Mechanical and Functionalization Properties. Journal of Biomedical Materials Research Part A (in press)

47. LC Shanley, OR Mahon, SA O'Rourke, NGB Neto, MG Monaghan, DJ Kelly, A Dunne Macrophage metabolic profile is altered by hydroxyapatite particle size.Acta Biomaterialia (in press)

46. MF Rooney, NGB Neto, MG Monaghan, EW Hill, RK PorterConditionally immortalised equine skeletal muscle cell lines for in vitro analysis. Biochemistry and Biophysics Reports 33, 101391

45. N Neto, M Suku, D Hoey, MG Monaghan. 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified bioRxiv, https://doi.org/10.1101/2023.01.13.52389

2022

44. Solazzo M, Monaghan MG. Hydrophilic, conductive and flexible piezoresistive PEDOT:PSS 3D sensors with tunable microarchitecture and crosslinked using a PEGylated crosslinker. Synthetic Metals 2022 (Elsevier) 290 (1): 117157

43. O’Rourke SA, Neto NGB, Devilly E , Shanley LC, Fitzgerald HK , Monaghan MG† and Dunne A†. Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages. Atherosclerosis (Elsevier). 2022. 352 (1): 35-45.

42. Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade S, Hanlon M, Cunningham CC, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao L-Y, Monaghan MG, Nagpal S, Veale DJ, Fearon U. Distinct stromal and immune cell interactions shape the pathogenesis of Rheumatoid and Psoriatic Arthritis. Annals of the Rheumatic Diseases 2022;81:1224-1242.

41. Solazzo, Matteo; Hartzell, Linette; O'Farrell, Ciara; Monaghan, Michael. Beyond chemistry: Tailoring Stiffness and Microarchitecture to engineer highly sensitive biphasic elastomeric piezoresistive sensors. ACS Applied Materials and Interfaces. 2022. 2022, 14, 17, 19265–19277

40. Nuno GB Neto, Sinead A O’Rourke, Mimi Zhang, Hannah K Fitzgerald, Aisling Dunne, Michael G Monaghan. Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning. Elife 11, e77373

39.Achilleas Floudas* , Aine Gorman, Nuno Neto, Michael Gerard Monaghan, Zoe Elliott, Ursula Fearon and Viviana Marzaioli. Inside the joint of inflammatory arthritis patients: handling and processing of synovial tissue biopsies for high throughput analysis. Frontiers in Medicine. 2022. 9:830998

38. Groeber-Becker FK, Leikeim A, Wußmann M, Schmidt FF, Neto NGB, Benz F, Tiltmann K, Junger C, Monaghan MG, Schilling B. A Preclinical Model of Cutaneous Melanoma Based on Reconstructed Human Epidermis. Scientific Reports [Accepted in Press]; 2022. DOI: 10.21203/rs.3.rs-1193450/v1.

37. Fitzgerald, H.K.; O’Rourke, S.A.; Desmond, E.; Nuno G. B. Neto ; Monaghan, M.G.; Tosetto, M.; Doherty, J.; Ryan, E.J.; Doherty, G.A.; Nolan, D.P.; et al. The Trypanosoma brucei Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells. Antioxidants 2022, 15;11(1):164

2021

36. Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan R, Veale DJ, Fearon U. Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of Rheumatoid Arthritis. Annals of the Rheumatic Diseases 2022;81:193-205.

35. Saha U, Nairn R, Keenan O, Monaghan MG. A deeper insight into the influence of the electric field strength when Melt-Electrowriting on non-planar surfaces. Macromol Mater Eng. 2021. 306, 2100496

34. Fergal B. Coulter, Ruth E. Levey2, Scott T. Robinson, Stefano Deotti, Ryan Paetzold, Michael Monaghan, Peter Dockery, Eimear B. Dolan, Brian S. Coulter, James J. Prendergast, Liam P. Burke, Aoife J. Lowery, Rachel Beatty, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Monica Salamone, Carmelo M. Bruno, Giulio Ghersi, Kevin M. Moerman, Garry P. Duffy, Eoin O Cearbhaill. Additive Manufacturing of Multi-Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth. Adv. Healthcare Mater., 2021 10 (14), 2100229. https://doi.org/10.1002/adhm.202170063

33. Suku M, Forrester L, Biggs M, Monaghan MG. Resident Macrophages and their Potential in Cardiac Tissue Engineering. Tissue Eng: Part B, 2021. Accepted, In doi.org/10.1089/ten.teb.2021.0036.

32. Monaghan MG, Murphy CM. PREFACE: Old Drugs, New Tricks-Redefining Therapeutic Strategies for Tissue Regeneration Advanced drug delivery reviews, S0169-409X (21) 00097-1

31. Solazzo M, Monaghan MG. Structural crystallization of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications. Biomaterials Science 9 (12), 4317-4328

30. Perottoni, S., Neto, N. G., di Nitto, C., Dmitriev, R., Raimondi, MT. & Monaghan, MG. (2021) Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip. Lab on a Chip 21 (7), 1395-1408

2020

29. Achilleas Floudas, Nuno Neto, Viviana Marzaioli, Kieran Murray, Barry Moran, Michael G Monaghan, Candice Low, Ronan H Mullan, Navin Rao, Vinod Krishna, Sunil Nagpal, Douglas J Veale, Ursula Fearon. Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint. JCI insight, 5 (21), 2020.

28. Olvera D, Monaghan MG. Electroactive material-based biosensors for detection and drug delivery. .Advanced Drug Delivery Reviews 170, 396-424. https://doi.org/10.1016/j.addr.2020.09.011

27. Neto N, Dmitriev R, Monaghan MG. Seeing Is Believing: Noninvasive Microscopic Imaging Modalities for Tissue Engineering and Regenerative Medicine in, editor(s)Heinz Redl, Jeff Gimble, Darja Marolt Presen, Richard Oreffo and Susanne Wolbank , Tissue Engineering and Regeneration. Cell Engineering and Regeneration, Switzerland, Springer, 2020, ppAccepted- - In Press,

26. Ozaki E, Gibbons L, Neto N, Kenna P, Carty M, Humphries M, Humphries P, Campbell M, Monaghan M, Bowie A, and Doyle SL, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020

25. Ukkelman IA, Neto N, Papkovsky DB, Monaghan MG, Dmitriev RI., A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses., Redox biology, 30, 2020, p101420

24. Olvera D., Sohrabi Molina M., Hendy G., Monaghan M.G., Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium, Advanced Functional Materials, 2020

2019

23. Solazzo M, O'Brien F.J. , Nicolosi V, Monaghan M.G, The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering, APL Bioeng. 2019, 3: (4), 041501, DOI: 10.1063/1.5116579.

22. Dolan E.B, Varela C. E, Mendez K, Whyte W, Levey R. E, Robinson S. T, Maye E, O’Dwyer J, Beatty R, Rothman A, Fan Y, Hochstein J, Rothenbucher S. E, Wylie R, Starr J. R, Monaghan M, G, Dockery P, Duffy G. P, Roche E. T. An actuatable soft reservoir modulates host foreign body response. Science Robotics. (2019)In Press

21. O’Rourke S, Dunne A, Monaghan M.G, The role of macrophages in the infarcted myocardium: orchestrators of ECM remodelling. Frontiers Cardiovasc Med. 6 (2019), 101.  

20. Solazzo M, Krukiewicz K, Zhussupbekova A, Fleischer K, Biggs M.J, Monaghan M.G, . PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility. RSC J Mater Chem B., 2019 DOI: 10.1039/C9TB01028A – In Press

19. Dolan E.B., Hofmann B., Hammande Vaal M., Bellavia G., Straino S., Kovarova L., Pravda M., Velebny V., Daro D., Braun N., Monahan D.S., Levey R.E., O'Neill H., Hinderer S., Greensmith G., Monaghan M.G., Schenke-Layland K., Dockery P., Murphy B.P., Kelly H.M., Wildhirt S., Duffy G.P. A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction. Mater. Sci. Eng. C103 (2019) 109751.

2018

18. Shen N, Riedl JA, Carvajal-Berrio DA, Davis Z, Monaghan MG, Layland SL, Hinderer S, Schenke-Layland K. A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy..Biomed. Mater. 13 (2018) 024101

17.  Monaghan M.G, Holeiter M, Brauchle E, Layland S.L, Lu Y, Deb A, Pandit A, Nsair A, Schenke-Layland K. Exogenous mir-29B delivery via a hyaluronan-based injectable system yields functional maintenance of the infarcted myocardium. Tissue Eng Part A. 24 (2018) 57–67.

2017

16. Lotz C, Schmid F.F, Oechsle E, Monaghan M, Walles H, Groeber-Becker F.K. A crosslinked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents. CS Appl. Mater. Interfaces 9 (2017) 20417–20425

15. Lakner P.H*, Monaghan M. G*, M, Möller Y, Olayioye M.A, Schenke-Layland K. Applying a phasor approach analysis of multiphoton fluorescence lifetime imaging microscopy   measurements to probe the metabolic activity of three-dimensional in vitro cell culture models.  Sci Rep. 7 (2017) 42730. (*Both authors contributed equally).

2016

14. Brauchle E, Knopf A, Bauer H, Shen N, Linder S, Monaghan M.G, Ellwanger K, Layland S.L, Brucker S.Y, Nsair A, Schenke-Layland K. Non-invasive chamber-specific identification of cardiomyocytes in differentiating pluripotent stem cells. Stem Cell Rep. 6 (2016) 188-99.

13. Monaghan M.G, Holeiter M, Layland S.L, Schenke-Layland K, Cardiomyocyte generation from somatic sources - current status and future directions. Curr Opin Biotechnol., 40 (2016) 49-55.

12. Monaghan M.G, Linneweh M, Liebscher S, van Handel B, Layland S.L, Schenke-Layland K. Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development. Development, 143 (2016) 473-482.

11. Monaghan M.G, Kroll S, Brucker S.Y, Schenke-Layland K, Enabling multiphoton and second harmonic generation imaging in paraffin embedded and histologically stained sections. Tissue Eng Part C Methods, 22 (2016) 517-23.

2015

10. Dash, B.C., Thomas, D., Monaghan, M., Carroll, O., Chen, X., Woodhouse, K., O'Brien, T., Pandit, A., An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia, Biomaterials, 65, 2015, p126-139

9. Browne S, Monaghan M, Brauchle E, Carvajal Berrio D, Chantepie-Laborde S, Papy-Garcia D, Schenke-Layland K, Pandit A. Modification of inflammation and angiogenesis and changes in the ECM GAG-activity via dual delivery of nucleic acids. Biomaterials, 69 (2015) 133-47.

8. Groeber F, Engelhardt L, Egger S, Werthmann H, Monaghan M, Walles H, Hansmann J. Impedance spectroscopy for the non-destructive evaluation of in vitro epidermal model. Pharm Res., 32 (2015) 1845-54.

7. Dash BC, Thomas D, Monaghan M, Carroll O, Woodhouse K, O’Brien T, Pandit A. Delivery of therapeutic eNOS and IL-10 plasmids for the treatment of critical limb ischemia, Biomaterials, 65 (2015) 126-39.

2010-2014

6. Schesny M, Monaghan M, Bindermann A, Freund D, Seifert M, Eble J, Hinderer S, Schenke-Layland K. Preserved bioactivity and tunable release of a SDF1-GPVI bispecific protein using photocrosslinked PEGda hydrogels, Biomaterials, 35 (2014) 7180-7187.

5. Monaghan M, Browne S, Schenke-Layland K, Pandit A. A collagen-based scaffold delivering exogenous microRNA-29B to modulate extracellular matrix remodelling. Mol Ther., 22 (2014) 786-789.

4. Monaghan M, Greiser U, Wall J.G, O'Brien T, Pandit A. Interference: An alteRNAtive therapy following acute myocardial infarction. Trends Pharmacol Sci., 2012, 33: 635-645.

3. Monaghan M, Greiser U, Cao H, Wang W, Pandit A. A ligand enhanced dendritic PEGylated poly (2-(dimethylamino) ethyl diacrylate) as a vehicle of microRNA, Drug Del Trans Res.,2 (2011) 406-414.

2. Monaghan M, Pandit A. RNA interference therapy via functionalized scaffolds, Adv Drug Del Rev., 63 (2011) 197-208.

1. Dash B.C, Réthoré G, Monaghan M, Fitzgerald K, Gallagher W, Pandit A. The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility, Biomaterials, 31 (2010) 8188-8197.

Published as part of conference proceedings (Peer Reviewed):

Book Chapters:

International Conference/Meeting Abstracts:

  • Lakner P, Möller Y, Olayioye M, Brucker S.Y, Schenke-Layland K, Monaghan, M.G. A Phasor approach analysis of multiphoton FLIM measurements of three-dimensional cell culture models. Podium Presentation at the SPIE Photonics West meeting 2016, San Francisco, CA, USA. 13th -18th February 2016.

  • Molina-Arce C, Brauchle E, Monaghan M.G, Holeiter M, Schenke-Layland K. Characterization of extracellular matrix in murine scar tissues with near infrared Raman microspectroscopy, Podium Presentation at the Innovation Match MX, Guadalajara, Mexico, 6th-8th April 2016.

  • Monaghan M, Brauchle E, Carvajal Berrio D, Deb A, Pandit A, Nsair A, Schenke-Layland K. Biomaterial delivery of exogenous miR-29b to the infarcted myocardium yields improved myocardial recovery, Podium Presentation at the World Congress of the Tissue Engineering and Regenerative Medicine International Society, Boston, MA, USA, 8th-11th September 2015

  • Maurer M, Monaghan M, Möller Y, Olayioye M, Schenke-Layland K. Single-cell transfection within a 3D tumor model using optoporation, Podium Presentation at the Biomedical Engineering Society Annual Meeting, San Antonio, Texas, 22nd-25th October 2014

  • Monaghan M, Browne S, Schenke-Layland K, Pandit A. A Collagen-based Scaffold Delivering Exogenous microRNA-29B to Modulate Extracellular Matrix Remodeling Podium Presentation at the Meeting of the German Matrix Biology Society (DGMB), Regensburg, Germany, 20th-22nd March 2014

  • Monaghan M, Browne S, Wang W, Pandit A. Delivery and efficacy of interfering RNA via a crosslinked collagen hydrogel in an excisional in vivo model and a human pre‐clinical model to reduce fibrosis, Podium Presentation at World Congress of Tissue Engineering and Regenerative Medicine International Society, Vienna, Austria, 5th – 8th September 2012

  • Monaghan M, Browne S, Wang W, Pandit A. Delivery and efficacy of interfering RNA via a crosslinked collagen hydrogel in an excisional in vivo model and a human pre‐clinical model to reduce fibrosis, Podium Presentation at the 3rd International Conference "Strategies in Tissue Engineering, Würzburg, Germany, 23rd-25th May 2012

  • Monaghan M, Browne S, Wang W, Pandit A. Scaffold-mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, Podium Presentation at the World Conference in Regenerative Medicine, Leipzig, Germany, 2nd- 4th November 2011

  • Monaghan M, Browne S, Wang W, Pandit A. Scaffold-mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, Podium Presentation at the European Society of Biomaterials Conference, Dublin, Ireland. 4th – 9th September 2011

  • Kelly J.L, Doody J, Zeugolis D, Monaghan M, Kelly G, Devocelle M, Kilcoyne M, Joshi L, Pandit A. Collagen fibers modified with polysialic mimetic peptide are a suitable material for use as a synthetic peripheral nerve graft. Podium Presentation at the Irish Association of Plastic Surgery Meeting, Dublin, Ireland, 26th November 2010

  • Dash B.C, Mahor S, Monaghan M, Woodhouse K.A, Pandit A. Elastin like protein based hollow spheres for gene delivery, Podium Presentation at the European Society of Biomaterials Conference, Tampere, Finland, 11th -15th September 2010

  • Monaghan M, Mathew A, Greiser U, Wang W, Pandit A. Scaffold mediated delivery of microRNA immunopolyplexes, Podium Presentation at the European Society of Biomaterials Conference, Tampere, Finland, 11th -15th September 2010

  • Monaghan M, Mathew A, Greiser U, Wang W, Pandit A. Scaffold mediated delivery of microRNA immunopolyplexes, Podium Presentation at the Tissue Engineering and Regenerative Medicine Conference, Galway, Ireland, 14th – 17th June 2010

  • Dash B C, Mahor S, Monaghan M, Woodhouse K A, Pandit A. Elastin like protein based hollow spheres for gene delivery, Podium Presentation at the Tissue Engineering and Regenerative Medicine Conference, Galway, Ireland, 14th – 17th June 2010

  • Mathew A, Monaghan M, Wang W, Pandit A. A linear-dendritic hybrid poly (2-(dimethylamino) ethyl methacrylate) as a highly effective gene delivery vector, Podium Presentation at the European Society of Biomaterials Conference, Tampere, Finland, 11th -15th September 2010

  • Réthoré G, Monaghan M, Dash B C, Pandit A. Chitosan-polyglutamic acid biodegradable nanospheres show a blood compatibility response that is dictated by size and surface charge, Podium presentation at the 2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society, Seoul, Republic of Korea, 2009

  • Matthew A, Réthoré G, Dash B C, Monaghan M, Pandit, A. Chitosan/polyglutamic acid nanospheres: DNA encapsulation and release, cellular uptake and blood interaction studies, Podium presentation at the UK Society for Biomaterials Conference, Antrim, UK, 2009